The average and likely maximum human lifespan significantly higher than that of any other mammals. This can be partly explained by advances in medicine, aimed primarily to help people, but the Central role played by features of the genome of Homo sapiens. In a recent study, experts found that longevity people have an accumulation of mutations in the protein p62.
Previously it was known that the protein р62 helps to protect the body from stress and is involved in the launch of the process by which cells are removed from the damaged components. However, until now, experts have known that how significant is its role to ensure a high life expectancy. At the same time, it was known that some mutations leading to age-related neurodegenerative diseases also affect the p62.
The experts brought in genetically modified Drosophila version of the p62 protein that resembles a human. In the result of fruit flies with ‘humanized’ protein could much longer survive under stress. According to scientists, this shows that the mutation of this protein accumulated in humans during evolution, help to live longer and man. At the same time, scientists clarify that in more comfortable conditions, life expectancy genetically modified Drosophila have not changed and they grew old at the same rate, so scientists recognize that the identified mechanism is not the only, to ensure the people’s longevity.
According to scientists, their study not only allows you to better understand the principles that determine the lifespan of different organisms, but can be of practical use — derived data, are likely to develop more effective methods to prevent and combat neurodegenerative diseases at the genetic level are related to the functioning of the studied protein.
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