The application of the University of Pennsylvania to conduct human genetic modification has received the approval of the Advisory Committee on recombinant DNA at the National Institute of health, USA. Using technology for genome editing CRISPR/Cas9 experts hope to try out a new technique to combat cancer, which can show itself to be highly effective. Still, any projects involving the editing of the genome of people, such permits are not received.
In the experiment, the experts will extract the T-lymphocytes of patients with different cancer types ( melanoma, sarcoma, or myeloma). Subsequently, these cells are “edited” by changing multiple genes in them, and again put in the human body, then these cells would be expected to very actively fight the tumor, and cancer cells cannot identify T-lymphocytes as immune cells and will not be able to “disable”. None of the methods of editing the genome that have existed until now, did not allow such significantly modify the cells.
On the planned experiment, writes the journal Science. For it professionals will require a number of permissions from Management on sanitary inspection behind quality of foodstuff and medicines of the USA, and also medical centers in which relevant studies are planned.
Research on interventions in the human genome, always meet with mixed reactions from academics and members of the public and spark debate on the topic, where is the line between the need of development of medicine and the ethical inadmissibility of intervention in the very human nature. Anyway, various news, one way or another affecting this issue, in recent times, appear with enviable regularity. Earlier this month, for example, the Dutch authorities declared readiness in the near future to allow the growing of human embryos for further use in the experiments. After a few days in the journal Nature published an article, which the authors suggested that the first “children from three parents” (in addition to paternal and maternal genes with mitochondrial DNA from another woman) will appear in the next year. And recently in the latest issue of the same journal published a study which the authors propose a project to raise the human genome “from scratch” of individual genes.Related posts: