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Wednesday, February 21, 2018

Antibiotics dangerous for the brain

A group of experts representing the Center for molecular medicine the name of max delbrück in Germany, made a statement that antibiotics for extended periods of time can lead to problems with memory and deterioration of other functions of the human brain. According to researchers, the reason being that the immune cells involved in the transmission of information between the brain and the intestine.

photo: Natalia Muslinkina

A study conducted by biologists showed that a long course of antibiotics provokes the decrease in the nucleation rate of new brain cells. This is primarily manifested in the hippocampus — part of limbic system in the brain that is involved, including, in the transition of short-term memory into long-term, as well as in the formation of emotions.

In order to come to these conclusions, the experts conducted an experiment on laboratory mice, some of which in water was added antibiotics, while the other was a control group.

As might be expected, the antibiotics have done the intestinal microflora of mice poorer. However, experts have noticed one more important detail: reducing the number of microorganisms in the gut was accompanied by the fact that fewer mice became and certain immune cells located in the brain of monocytes Ly6C(hi). As shown by additional experiments, their number is directly dependent on the rate of neurogenesis.

In the future, scientists managed to restore immune cells and the normal functioning of the brain, after one of them in the intestines imposed certain strains of bacteria, while others were given the opportunity to run in a wheel to restore health. At the same time, the mice, who simply “transplanted” bacteria rodents from the control group, it did not help.

The researchers emphasize that their work should not be too far — reaching conclusions- the experiment was conducted on mice and it used a “cocktail” of powerful antibiotics, therefore, to say that the course of any antibiotics has a significant impact on the human brain, at this stage of the study would be a significant exaggeration.

However, experts suggest that these data will allow a better understanding of the consequences of the use of antibiotics, and, probably, will help to effectively treat some people with such mental problems as schizophrenia or clinical depression.

His research scientists published in the journal Cell Reports.

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